溶葡萄球菌酶与β-内酰胺类药物联合使用对耐苯唑西林表皮葡萄球菌具有协同作用。
Combinations of lysostaphin with beta-lactams are synergistic against oxacillin-resistant Staphylococcus epidermidis.
作者信息
Kiri Nandini, Archer Gordon, Climo Michael W
机构信息
Department of Medicine, Virginia Commonwealth University Health Science System, Richmond, Virginia 23249, USA.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):2017-20. doi: 10.1128/AAC.46.6.2017-2020.2002.
Abstract
Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-resistant Staphylococcus epidermidis (ORSE), which is normally less susceptible to lysostaphin. Checkerboard synergy testing was performed for lysostaphin given in combination with oxacillin against 10 ORSE isolates for which the lysostaphin MICs were > o r= 8 microg/ml. The fractional inhibitory concentration index ranged from 0.0234 to 0.2656, indicating synergy, which was confirmed in growth curve experiments. In the rabbit model of experimental aortic valve endocarditis using an ORSE strain, the combination of lysostaphin and nafcillin was as effective as vancomycin alone and significantly better than lysostaphin or nafcillin alone. We conclude that beta-lactam antibiotics given in combination with lysostaphin are synergistic against many strains of ORSE.
摘要
耐苯唑西林金黄色葡萄球菌可被内肽酶溶葡萄球菌素迅速杀灭，添加β-内酰胺类抗生素可产生协同杀菌作用。我们研究了β-内酰胺类药物与溶葡萄球菌素联合使用是否能提高溶葡萄球菌素对耐苯唑西林表皮葡萄球菌（ORSE）的活性，该菌通常对溶葡萄球菌素较不敏感。对溶葡萄球菌素与苯唑西林联合使用针对10株溶葡萄球菌素最低抑菌浓度（MIC）≥8μg/ml的ORSE分离株进行棋盘法协同试验。部分抑菌浓度指数范围为0.0234至0.2656，表明存在协同作用，这在生长曲线实验中得到了证实。在使用ORSE菌株的兔实验性主动脉瓣心内膜炎模型中，溶葡萄球菌素与萘夫西林联合使用的效果与单独使用万古霉素相同，且明显优于单独使用溶葡萄球菌素或萘夫西林。我们得出结论，β-内酰胺类抗生素与溶葡萄球菌素联合使用对许多ORSE菌株具有协同作用。
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LYSOSTAPHIN THERAPY IN MICE INFECTED WITH STAPHYLOCOCCUS AUREUS.溶葡萄球菌素对感染金黄色葡萄球菌小鼠的治疗作用
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