Miyazawa N, Suzuki S
First Department of Internal Medicine, Yokohama City University School of Medicine.
Nihon Rinsho. 1996 Nov;54(11):2914-8.
In bronchial asthma, pulmonary function tests are characterized by airway obstruction that is reversible either spontaneously or with treatment. In worsening of asthma, the parameters of FEV1, V50, V25 and RV decrease and those of sGaw and CV increase. However, compliance and diffusing capacity are within normal limits, and are very sensitive in differentiating asthma from emphysema. FEV1 is reproducible and sensitive in assessing the changes in airway caliber. Reversibility of airway obstruction is demonstrated when FEV1, is increased by more than 0.2 L or 15% of the baseline after inhalation of a beta-agonist. In severe asthma, the measurements of arterial blood gases and expiratory flow rates are essential.
在支气管哮喘中,肺功能测试的特征是气道阻塞,这种阻塞可自发或通过治疗逆转。在哮喘加重时,第一秒用力呼气容积(FEV1)、50%肺活量时的最大呼气流量(V50)、25%肺活量时的最大呼气流量(V25)和残气量(RV)参数下降,而比气道传导率(sGaw)和顺应性(CV)参数增加。然而,肺顺应性和弥散能力在正常范围内,且在区分哮喘和肺气肿方面非常敏感。FEV1在评估气道管径变化时具有可重复性且敏感。吸入β受体激动剂后,若FEV1增加超过0.2 L或超过基线的15%,则表明气道阻塞具有可逆性。在重度哮喘中,动脉血气和呼气流量率的测量至关重要。