Kitamura S, Sugama Y
Department of Pulmonary Medicine, Jichi Medical School.
Nihon Rinsho. 1996 Nov;54(11):3078-80.
Beta-agonist is a widely used bronchodilator. Although it has an ability to dilate bronchus rapidly, it shows no or minimal relief for severe asthma and no effect on the inflammation which is thought as a most important factor in disease of asthma. Some reports showed that the regular use of inhaled beta 2 agonist induced hypersensitivity of bronchoconstriction, and some showed that the overdose of inhaled beta 2 agonist induced an increase of asthma death. We should discuss how we use inhaled beta 2 agonist systematically now. Depends on the several guidelines, inhaled beta 2 agonist can be used on demand for mild and moderate asthma, and if inhaled beta 2 agonist need to be used regularly for more severe condition of asthma, inhaled corticosteroid and anti-inflammatory agents should be started. Inhaled beta 2 agonist can be used up to 4 times a day. To save the dose of inhaled beta 2 agonist for the control of asthma, the use of a handy peak flow meter will be beneficial.
β-激动剂是一种广泛使用的支气管扩张剂。尽管它有迅速扩张支气管的能力，但对重度哮喘几乎没有缓解作用，对被认为是哮喘疾病最重要因素的炎症也没有效果。一些报告显示，长期使用吸入性β2激动剂会导致支气管收缩过敏，还有一些报告显示，吸入性β2激动剂过量会导致哮喘死亡率上升。我们现在应该系统地讨论如何使用吸入性β2激动剂。根据一些指南，吸入性β2激动剂可按需用于轻度和中度哮喘，如果对于更严重的哮喘病情需要定期使用吸入性β2激动剂，则应开始使用吸入性糖皮质激素和抗炎药。吸入性β2激动剂每天最多可使用4次。为了节省吸入性β2激动剂的剂量以控制哮喘，使用便捷的峰流速仪会有帮助。
