Ogawa C, Sano Y
Department of Allergy and Respiratory Medicine, Doai Memorial Hospital.
Nihon Rinsho. 1996 Nov;54(11):3081-6.
We examined the effects of two year's treatment of three inhaled beta 2-agonists (beta 2), such as salbutamol (S), procaterol (P) and fenoterol (F) on acetylcholine induced bronchial hyperresponsiveness (BHR) in mild approximately moderate asthmatics. When symptomatic use of beta 2 were less than 6 puffs/day, BHR was improved significantly with both S and P but was not with F. When more than 6 puffs/day, all three beta 2 did not show the improvement of BHR. Without the effect of corticosteroids, BHR was improved with S, and was partially improved with P in case of only less than 6 puffs/day, but was not improved with F unrelated to the inhaled puff number. Therefore, frequent use of beta 2 even if used only on demand was shown to worse BHR, asthmatics must be controlled to under the good condition of using beta 2 at least less than 6 puffs/day.
我们研究了三种吸入性β2受体激动剂（β2），即沙丁胺醇（S）、丙卡特罗（P）和非诺特罗（F），对轻度至中度哮喘患者进行为期两年治疗后，乙酰胆碱诱导的支气管高反应性（BHR）的影响。当β2受体激动剂的症状性使用量小于每日6吸时，S和P均可显著改善BHR，但F无此作用。当每日使用量超过6吸时，所有三种β2受体激动剂均未显示出BHR的改善。在无皮质类固醇作用的情况下，S可改善BHR，仅在每日使用量小于6吸时P可部分改善BHR，但无论吸入剂量多少，F均不能改善BHR。因此，即使仅按需使用β2受体激动剂，频繁使用也会使BHR恶化，哮喘患者必须控制在至少每日使用β2受体激动剂少于6吸的良好状态。
