Elsässer-Beile U, Willenbacher W, Bartsch H H, Gallati H, Schulte Mönting J, von Kleist S
Institute of Immunobiology, Medical Faculty, University of Freiburg, Germany.
J Clin Lab Anal. 1996;10(6):441-5. doi: 10.1002/(SICI)1098-2825(1996)10:6<441::AID-JCLA22>3.0.CO;2-W.
We measured the levels of the cytokines IL-1-alpha, IL-1-beta, IL-2, IL-6, TNF-alpha, and IFN-gamma in culture supernatants of stimulated whole blood cells derived from 23 tumor patients undergoing a 4-week oral treatment with a spagyric extract from Echinacea angustifolia, Eupatorium perfoliatum, and Thuja occidentalis (Echinacea complex). All patients had had curative surgery for a localized solid malignant tumor. Blood was taken before treatment and after 2 and 4 weeks of therapy. Twelve untreated tumor patients at the same clinical stage, also after curative surgery, served as a control group. In the blood cell cultures of all patients, a rather wide range of cytokine levels was found. After therapy with Echinacea complex, no significant alteration in the production of the cytokines could be seen in comparison to the controls, and also the leukocyte populations remained constant. We conclude that at this application and dosage, the therapy with Echinacea complex has no detectable effect on tumor patients' lymphocytes activity as measured by their cytokine production.
我们检测了23例接受为期4周口服紫锥菊、贯叶泽兰和北美香柏（紫锥菊复合物）炮制提取物治疗的肿瘤患者的全血细胞培养上清液中细胞因子白细胞介素-1α（IL-1-α）、白细胞介素-1β（IL-1-β）、白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）的水平。所有患者均接受了局限性实体恶性肿瘤的根治性手术。在治疗前以及治疗2周和4周后采集血液。12例处于相同临床分期且同样接受了根治性手术的未治疗肿瘤患者作为对照组。在所有患者的血细胞培养物中，发现细胞因子水平范围相当广泛。与对照组相比，用紫锥菊复合物治疗后，细胞因子的产生没有明显变化，白细胞群体也保持不变。我们得出结论，在这种应用和剂量下，用紫锥菊复合物治疗对肿瘤患者淋巴细胞活性（通过细胞因子产生来衡量）没有可检测到的影响。
