Toborek M, Hennig B
Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA.
Med Hypotheses. 1996 Nov;47(5):377-82. doi: 10.1016/s0306-9877(96)90217-0.
Injury or dysfunction of the vascular endothelium is one of the first events in the development of atherosclerosis. Individual lipids, e.g. fatty acids or lipoproteins, are among the most critical factors which may induce injury to the endothelium. Selected fatty acids, such as linoleic acid, can disrupt endothelial barrier function and increase the inflammatory response of the vascular endothelium. The mechanisms of these processes are not fully understood. It is hypothesized that selected fatty acids can mediate the autocrine production of tumor necrosis factor-alpha in endothelial cells. This will activate a variety of intracellular signaling pathways and further potentiate endothelial injury initially induced by fatty acids.
血管内皮损伤或功能障碍是动脉粥样硬化发展过程中的早期事件之一。个别脂质，如脂肪酸或脂蛋白，是可能导致内皮损伤的最关键因素。某些脂肪酸，如亚油酸，可破坏内皮屏障功能并增强血管内皮的炎症反应。这些过程的机制尚未完全明了。据推测，某些脂肪酸可介导内皮细胞中肿瘤坏死因子-α的自分泌产生。这将激活多种细胞内信号通路，并进一步加重最初由脂肪酸诱导的内皮损伤。
