Kubota K
Department of Behavioral and Brain Sciences, Kyoto University, Aichi, Japan.
Neuroreport. 1996 Oct 2;7(14):2379-84. doi: 10.1097/00001756-199610020-00020.
To investigate how GABAA inhibition in the motor cortex is involved in motor control in freely moving infant macaque monkeys, muscimol, a GABAA agonist, was injected into the hand motor area and changes in movement parameters of visual reaching during apple pickup tests or a delayed response task were examined. After the injection (30 micrograms microliters-1) the monkeys tended to use the contralateral hand, and the ipsilateral hand showed a posture of dropped wrist and fingers, as if the radial nerve were paralysed. Movement time and/or reaction time of the ipsilateral hand was prolonged. Motorcortical GABAA inhibition is important for initiation of smooth flexion and/or extension movement of the hand and fingers.
为了研究运动皮层中γ-氨基丁酸A型（GABAA）抑制如何参与自由活动的幼年猕猴的运动控制，将GABAA激动剂蝇蕈醇注射到手部运动区，并在苹果抓取测试或延迟反应任务期间检查视觉够物运动参数的变化。注射（30微克微升-1）后，猴子倾向于使用对侧手，同侧手呈现手腕和手指下垂的姿势，就好像桡神经麻痹了一样。同侧手的运动时间和/或反应时间延长。运动皮层的GABAA抑制对于手部和手指平滑屈伸运动的启动很重要。
