Kerlin R L, Hendrick M J
Laboratory of Pathology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Vet Pathol. 1996 Nov;33(6):713-6. doi: 10.1177/030098589603300614.
Malignant fibrous histiocytoma (MFH) and malignant histiocytosis (MH) are neoplasms with different histologic appearances and consequently a different putative cell of origin. Recently, the biopsy and necropsy services at the University of Pennsylvania have seen many canine soft tissue sarcomas that have the gross and histologic appearances of both MH and MFH within the same animal. A retrospective histologic evaluation of 263 cases diagnosed originally as either MH or MFH reclassified these neoplasms into 77 cases that were exclusively MH, 110 cases exclusively MFH, and 76 cases with features of both MH and MFH. Age, sex, breed predispositions, and distribution of lesions in organs were remarkably similar between the two categories. The hybrid neoplasms containing MH-like and MFH-like regions may be the result of divergent or convergent phenotypic differentiation.
恶性纤维组织细胞瘤（MFH）和恶性组织细胞增多症（MH）是具有不同组织学表现的肿瘤，因此其假定的起源细胞也不同。最近，宾夕法尼亚大学的活检和尸检服务部门发现了许多犬软组织肉瘤，同一动物体内的这些肉瘤在大体和组织学表现上兼具MH和MFH的特征。对最初诊断为MH或MFH的263例病例进行回顾性组织学评估后，将这些肿瘤重新分类为：77例仅为MH，110例仅为MFH，76例兼具MH和MFH的特征。这两类肿瘤在年龄、性别、品种易感性以及器官内病变分布方面非常相似。含有MH样和MFH样区域的混合性肿瘤可能是分化或趋同表型分化的结果。
