[人类免疫缺陷病毒感染中的尿卟啉排泄]
[Urinary porphyrin excretion in human immunodeficiency virus infection].
作者信息
Mouly F, Janier M, Nordmann Y, Flageul B
机构信息
Policlinique de Dermatologie, Hôpital Saint-Louis, Paris.
出版信息
Presse Med. 1996 Oct 26;25(32):1541-5.
OBJECTIVES
Porphyria cutanea tarda has been reported in about 60 patients with human immunodeficiency virus (HIV) since 1987. We looked for porphyrin metabolism disorders in HIV infected patients without patent porphyria cutanea tarda.
METHODS
Urinary porphyrin excretion was measured in 64 patients with an HIV infection.
RESULTS
Excreted levels were abnormal in 23 patients (36%) including 4 (6%) with patterns highly suggestive of porphyria cutanea tarda. One of these patients developed the disease 2 years later. In 15 patients (23%) there was a significant increase in coproporphyrinuria. Minimal alterations in uroporphyrin or its precursors were seen in the other patients. Abnormal excretion was significantly more frequent in patients with hepatopathy and in patients who had progressed to AIDS.
CONCLUSION
Our findings suggest that HIV infection does not play a direct role in altered porphyrin metabolism because of the frequency of liver disorders observed in these patients.
目的
自1987年以来，已报道约60例人类免疫缺陷病毒（HIV）感染患者患有迟发性皮肤卟啉症。我们在无明显迟发性皮肤卟啉症的HIV感染患者中寻找卟啉代谢紊乱情况。
方法
检测了64例HIV感染患者的尿卟啉排泄情况。
结果
23例患者（36%）排泄水平异常，其中4例（6%）的排泄模式高度提示迟发性皮肤卟啉症。这些患者中有1例在2年后患上了该病。15例患者（23%）的粪卟啉尿症显著增加。其他患者尿卟啉或其前体仅有轻微改变。肝病患者和已进展至艾滋病的患者排泄异常明显更常见。
结论
我们的研究结果表明，由于在这些患者中观察到肝脏疾病的发生率，HIV感染在卟啉代谢改变中不发挥直接作用。
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