McMurray R W
Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.
Ann Med Interne (Paris). 1996;147(4):253-8.
Prolactin in a pituitary peptide hormone which is immunomodulatory. Increased serum prolactin concentrations accelerate autoimmunity in the NZB x NZW F1 mouse model of SLE. Some patients with SLE are hyperprolactinemic and, in cross-sectional and longitudinal studies, serum prolactin has been associated with or correlated to lupus disease activity. Suppression of physiologic levels of prolactin by bromocriptine administration was associated with improvement in SLE in a preliminary study. While specific mechanisms remain to be elucidated, prolactin appears to be immunostimulatory in patients with SLE. A better understanding of its role and its interactions with other immunoregulatory hormones in SLE may lead to novel therapies for the suppression of this hormonally sensitive autoimmune disease.
催乳素是一种具有免疫调节作用的垂体肽类激素。在新西兰黑鼠与新西兰白鼠杂交的F1小鼠系统性红斑狼疮（SLE）模型中，血清催乳素浓度升高会加速自身免疫反应。一些SLE患者存在高催乳素血症，在横断面和纵向研究中，血清催乳素与狼疮疾病活动相关或具有相关性。在一项初步研究中，使用溴隐亭抑制生理水平的催乳素与SLE病情改善相关。虽然具体机制仍有待阐明，但催乳素在SLE患者中似乎具有免疫刺激作用。更好地了解其在SLE中的作用及其与其他免疫调节激素的相互作用，可能会带来抑制这种激素敏感性自身免疫性疾病的新疗法。
