Radet C, Champion G, Grimal I, Duverne C, Coupris L, Ginies J L, Limal J M
Département de pédiatrie B, centre Robert-Debré, CHU, Angers, France.
Arch Pediatr. 1996 Nov;3(11):1069-78. doi: 10.1016/s0929-693x(96)89511-x.
Malformative uropathies diagnosed in utero are increasing in number. This work describes the decision strategy adopted in Angers concerning the neonatal handling of those abnormalities.
One hundred children born between 1988 and 1990, with prenatally suspected fetal uropathy, were included in the study and followed for a period of 3 years. In every case, an ultrasound scan was performed at birth. In cases with persistent abnormality, a voiding cystourethrography was done in the first week of life. An intravenous urograph and/or a nuclear renography were performed during the second month of life.
Twenty-nine children were normal. Seventy-one were affected by 126 isolated or related uropathies; the most frequent ones were the ureteropelvic junction obstruction syndrome (48), ureterovesical junction obstruction (18) and multicystic kidneys (13). A vesicoureteral reflux was associated in 22% of cases. The diagnosis was perfectly correlated with the prenatal diagnosis in 50% of cases. Fourteen of the normal children had a later ultrasound scan control, between 2 and 9 months; later on, three of them showed a moderate ureteropelvic junction obstruction syndrome. Amongst the 48 ureteropelvic junction obstruction syndromes, 22% have been operated on. The others obstructive uropathies remained stable or spontaneously improved.
These results require us to discuss as matter of priority the large number of spontaneously regressive prenatal hydronephrosis and the necessity to establish a consensus for the pre and postnatal pathological thresholds of the anteroposterior pelvic diameter, the interest in carrying out a voiding cystography after the birth when dilatation is confirmed, the interest of nuclear renography for the diagnosis and follow-up of obstructive uropathies and the absence of urgency for surgery.
We propose a decision tree specifying the action to take when facing the diagnosis of a prenatal hydronephrosis. It could be a part of the reflection for the medical teams handling these uropathies is the aim of a consensual attitude which is now essential.
子宫内诊断出的发育异常性尿路疾病数量正在增加。这项工作描述了昂热在处理这些新生儿异常情况时所采用的决策策略。
1988年至1990年间出生的、产前怀疑患有胎儿尿路疾病的100名儿童被纳入研究,并随访3年。每个病例在出生时均进行超声检查。对于持续存在异常的病例,在出生后第一周进行排尿性膀胱尿道造影。在出生后第二个月进行静脉肾盂造影和/或核素肾造影。
29名儿童正常。71名儿童受126种孤立或相关的尿路疾病影响;最常见的是输尿管肾盂连接部梗阻综合征(48例)、输尿管膀胱连接部梗阻(18例)和多囊肾(13例)。22%的病例伴有膀胱输尿管反流。50%的病例诊断与产前诊断完全相符。14名正常儿童在2至9个月之间进行了后期超声检查;后来,其中3名儿童显示出中度输尿管肾盂连接部梗阻综合征。在48例输尿管肾盂连接部梗阻综合征中,22%进行了手术。其他梗阻性尿路疾病保持稳定或自行改善。
这些结果要求我们优先讨论大量自发消退的产前肾积水、为前后径骨盆的产前和产后病理阈值建立共识的必要性、出生后确认扩张时进行排尿性膀胱造影的意义、核素肾造影对梗阻性尿路疾病诊断和随访的意义以及手术的紧迫性。
我们提出了一个决策树,明确了面对产前肾积水诊断时应采取的行动。它可以成为处理这些尿路疾病的医疗团队思考中的一部分,其目的是达成共识的态度,而这在现在是必不可少的。