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[二氧化碳支气管激光治疗小儿支气管肺发育不良所致获得性气管支气管狭窄]

[Treatment by CO2 broncho-laser for acquired tracheobronchial stenosis in children with bronchopulmonary dysplasia].

作者信息

Wagner I, Ayache D, Denoyelle F, Garabédian E N

机构信息

Service d'ORL pédiatrique et de chirurgie cervicofaciale, hôpital d'enfants Armand-Trousseau, Paris, France.

出版信息

Arch Pediatr. 1996 Nov;3(11):1079-83. doi: 10.1016/s0929-693x(96)89512-1.

Abstract

OBJECTIVE

Evaluation of carbon dioxide (CO2) broncholaser for treating acquired proximal tracheo-bronchial stenosis in children with bronchopulmonary dysplasia.

DESIGN

Retrospective study from June 1987 through August 1995, with 39 months follow-up.

PATIENTS AND METHODS

During the study, 65 children were treated for bronchopulmonary dysplasia. Eight of those (average age: 42.6 months) had symptomatic tracheo-bronchial stenosis; they were treated with CO2 broncholaser and represented 23.5% of all broncholaser applications. All patients presented multiple lesions. Ten symptomatic well-organized lesions (obstructive bridles or diaphragms), all accessible to broncholaser, were treated. Broncholaser was the primary treatment used, except in one case where it was used following balloon dilatation failure. An adaptable rigid fibroscope combined with a CO2 Sharplan laser was used. All interventions were performed under general anesthesia.

RESULTS

Lesions not reaching the trachea's bifurcation (eight cases) disappeared following one laser session with significant clinical improvement. Lesions extending to the trachea's bifurcation (two cases) only showed partial improvement despite three laser sessions. The results remained stable throughout the follow-up period. There were no major complications.

CONCLUSIONS

Broncholaser is a safe and efficient method of treating stenoses occurring in patients with bronchopulmonary dysplasias. Obstructive lesions (such as bridles or diaphragms) and those which do not reach the trachea's bifurcation, give the best results.

摘要

目的

评估二氧化碳(CO₂)支气管激光治疗支气管肺发育不良患儿获得性近端气管支气管狭窄的效果。

设计

1987年6月至1995年8月的回顾性研究,随访39个月。

患者与方法

研究期间,65例支气管肺发育不良患儿接受治疗。其中8例(平均年龄:42.6个月)有症状性气管支气管狭窄;他们接受了CO₂支气管激光治疗,占所有支气管激光治疗应用的23.5%。所有患者均有多处病变。对10个有症状的、组织良好的病变(阻塞性束带或膈膜)进行了治疗,所有病变均可通过支气管激光治疗。支气管激光是主要治疗方法,仅1例在球囊扩张失败后使用。使用了一种可适配的硬质纤维支气管镜与一台CO₂沙普蓝激光联合使用。所有干预均在全身麻醉下进行。

结果

未累及气管分叉的病变(8例)在一次激光治疗后消失,临床症状显著改善。累及气管分叉的病变(2例)尽管进行了三次激光治疗,仅显示部分改善。在整个随访期间结果保持稳定。无重大并发症。

结论

支气管激光是治疗支气管肺发育不良患者出现的狭窄的一种安全有效的方法。阻塞性病变(如束带或膈膜)以及未累及气管分叉的病变效果最佳。

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