Fortier B, Coignard-Chatain C, Soete M, Dubremetz J F
Service de Parasitologie et de Mycologie, CHRU, Lille, France.
C R Seances Soc Biol Fil. 1996;190(4):385-94.
Tachyzoite-bradyzoite interconversion is one characteristic feature of Toxoplasma gondii. Although highly similar in structure, tachyzoite and bradyzoite differ by the relative amount of certain organelles and by specific surface or cytoplasmic molecules. Differences in structure and contents also exist between parasitophorous vacuoles and cysts. Using stage specific markers, it was shown the quickness of stage switching in vivo as well as in vitro, together with the occurrence of intermediate stages. Regulatory mechanisms of interconversion remain unknown. However, stress or inhibition of the mitochondrial metabolism of the parasite trigger bradyzoite formation.
速殖子-缓殖子相互转化是刚地弓形虫的一个特征。尽管速殖子和缓殖子在结构上高度相似，但它们在某些细胞器的相对数量以及特定的表面或细胞质分子方面存在差异。寄生泡和包囊在结构和内容物上也存在差异。使用阶段特异性标记物，研究表明在体内和体外阶段转换的快速性，以及中间阶段的出现。相互转化的调控机制仍然未知。然而，寄生虫线粒体代谢的应激或抑制会触发缓殖子的形成。
