Jacques C, Berenbaum F
URA CNRS 1283, Faculté de Médecine Saint-Antoine, Paris, France.
C R Seances Soc Biol Fil. 1996;190(4):437-43.
Secreted phospholipase A2 has been detected in numerous inflammatory and infectious diseases. Since the cloning of the type II sPLA2 in 1989 from rheumatoid arthritis synovial fluid, a direct or indirect participation of type II sPLA2 in the production of lipid mediators has been purposed. This paper reviews the different studies from the literature alleging that type II sPLA2 participates to inflammatory processes and lipid mediators synthesis.
分泌型磷脂酶A2已在多种炎症和感染性疾病中被检测到。自1989年从类风湿性关节炎滑液中克隆出II型分泌型磷脂酶A2以来，有人提出II型分泌型磷脂酶A2直接或间接参与脂质介质的产生。本文综述了文献中的不同研究，这些研究称II型分泌型磷脂酶A2参与炎症过程和脂质介质合成。
