Deng G, Lu Y, Zlotnikov G, Thor A D, Smith H S
Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, USA.
Science. 1996 Dec 20;274(5295):2057-9. doi: 10.1126/science.274.5295.2057.
Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with this LOH in the carcinoma, six displayed the same LOH in adjacent normal lobules. This suggests that in a subset of sporadic breast cancers, a tumor suppresser gene at 3p22-25 may be important in initiation or early progression of tumorigenesis. Among sixteen breast cancers with LOH at 17p13.1 and five breast cancers with LOH at 11p15.5, one case each displayed the same LOH in adjacent normal lobules. Thus the molecular heterogeneity that characterizes invasive breast cancers may occur at the earliest detectable stages of progression.
在乳腺癌旁形态学正常的小叶中检测到杂合性缺失（LOH）。最常见的畸变位于染色体3p22 - 25；在癌组织中有这种LOH的10个病例中，6个在相邻正常小叶中显示相同的LOH。这表明在一部分散发性乳腺癌中，位于3p22 - 25的一个肿瘤抑制基因可能在肿瘤发生的起始或早期进展中起重要作用。在16例17p13.1存在LOH的乳腺癌和5例11p15.5存在LOH的乳腺癌中，各有1例在相邻正常小叶中显示相同的LOH。因此，侵袭性乳腺癌所特有的分子异质性可能在最早可检测到的进展阶段就已出现。
