Vieira A V, Lamaze C, Schmid S L
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Science. 1996 Dec 20;274(5295):2086-9. doi: 10.1126/science.274.5295.2086.
Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up-regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.
在受体介导的内吞作用存在条件缺陷的哺乳动物细胞中分析了表皮生长因子受体（EGFR）信号传导。在内吞作用缺陷的细胞中，表皮生长因子（EGF）依赖性细胞增殖增强。然而，早期的EGF依赖性信号转导事件并非均一性地上调。一部分信号转导分子需要EGFR正常的内吞运输才能实现完全激活。因此，活化的EGFR的内吞运输不仅在减弱EGFR信号传导中起关键作用，而且在建立和控制特定信号通路中也起关键作用。
