Clemis J D, Bland J, Fung C
Laryngoscope. 1977 Sep;87(9 Pt 1):1500-8. doi: 10.1288/00005537-197709000-00009.
The acinic cell tumor of salivary gland origin, once thought to be benign, is now known to be an incidiously slow growing malignant neoplasm with lethal potential. While the degree of malignant behavior of individual acinic cell tumors is notably variable, all must be treated with aggression. Traditional and current methods of treatment are reviewed; and, in conjunction with the tumors herein reported, guidelines for managment of this uncommon malignancy are suggested. Four cases have been reviewed in detail and critically analyzed. The pathology, including features of both light and electron microscopy, in included--particularly in relation to the oncocytoid areas identified in from 10% to 40% of the parenchymal cells of our tumors. Since an accurate histopathologic diagnosis is the first step in the establishment of a proper treatment plan, pitfalls in histologic diagnosis have been stressed.
涎腺来源的腺泡细胞肿瘤，曾被认为是良性的，现在已知是一种生长极为缓慢、具有致命潜能的恶性肿瘤。虽然单个腺泡细胞肿瘤的恶性行为程度差异显著，但所有病例都必须积极治疗。本文回顾了传统和当前的治疗方法，并结合本文报道的肿瘤病例，提出了这种罕见恶性肿瘤的管理指南。详细回顾并批判性分析了4例病例。包括病理情况，涵盖光镜和电镜特征，尤其涉及我们所研究肿瘤实质细胞中10%至40%发现的嗜酸性细胞区域。由于准确的组织病理学诊断是制定恰当治疗方案的第一步，因此强调了组织学诊断中的陷阱。
