Chomette G, Auriol M, Vaillant J M
J Biol Buccale. 1984 Jun;12(2):157-69.
Among 873 salivary gland tumors, 15 cases of acinic cell tumors were found (frequency of 1.6%). They occurred approximately evenly in man and women, the mean age being 41 years. They were located principally in the major salivary glands (12 cases in the parotid and 1 case in the submandibular gland) and only twice in accessory glands. Histologically, these tumors were divided into two groups: group I = highly differentiated tumors (less than 20% undifferentiated cells) and group II = poorly differentiated tumors (more than 20% undifferentiated cells). These histological feature seems to play a role in the clinical behaviour of these neoplasms. Thus, the 9 patients with highly differentiated tumors were alive and well 5 to 22 years after the treatment. On the other hand, 5 of the 6 patients with poorly differentiated tumors had local recurrences (4 cases) and lethal metastases to distant lymph nodes and bone (3 cases). The ultrastructural study corroborated the analogy of differentiated tumoral cells with normal acinic cells (numerous secretory granules and ergastoplasmic cisternae). Moreover, the undifferentiated cells had numerous ribosomes and their morphological structure was similar to that of intercalated duct cells. The histogenesis of this rare tumor is discussed. The acinic cell tumor seems more likely to arise from immature cells of intercalated ducts than from adult acinic cells.
在873例涎腺肿瘤中，发现15例腺泡细胞癌（发生率为1.6%）。男性和女性的发病情况大致相同，平均年龄为41岁。肿瘤主要位于大涎腺（腮腺12例，颌下腺1例），仅2例位于副涎腺。组织学上，这些肿瘤分为两组：I组=高分化肿瘤（未分化细胞少于20%）和II组=低分化肿瘤（未分化细胞多于20%）。这些组织学特征似乎在这些肿瘤的临床行为中起作用。因此，9例高分化肿瘤患者在治疗后5至22年仍存活且状况良好。另一方面，6例低分化肿瘤患者中有5例出现局部复发（4例）和远处淋巴结及骨的致死性转移（3例）。超微结构研究证实了分化的肿瘤细胞与正常腺泡细胞的相似性（有大量分泌颗粒和内质网池）。此外，未分化细胞有大量核糖体，其形态结构与闰管细胞相似。本文讨论了这种罕见肿瘤的组织发生。腺泡细胞癌似乎更可能起源于闰管的未成熟细胞而非成熟腺泡细胞。
