Nakai Y
Laryngoscope. 1977 Sep;87(9 Pt 1):1548-58. doi: 10.1288/00005537-197709000-00015.
In investigations on the action of DKB (3' 4'-dideoxykanamycin B), and aminoglycoside type drug, on the inner ears of mice and guinea pigs by means of scanning and transmission electron microscopy, it was evident that the action of DKB against the inner ear is similar to that of kanamycin. When the same type of investigation was performed using the diuretics furosemide and ethacrynic acid, changes were observed in the stria vascularis. When DKB and ethacrynic acid, which show no long lasting defects when given independently, were administered concurrently in the same doses, a very high level of degeneration was found in the organs of Corti of guinea pigs. From the above results, it is evident that when two or more types of ototoxic drugs are administered concurrently, they have a potentiating action on the ear and care should be taken clinically concerning this point.
通过扫描电子显微镜和透射电子显微镜对氨基糖苷类药物DKB（3' 4'-二脱氧卡那霉素B）对小鼠和豚鼠内耳作用的研究表明，DKB对内耳的作用与卡那霉素相似。当使用利尿剂速尿和依他尼酸进行同样类型的研究时，发现血管纹有变化。当单独给药时不会造成长期损害的DKB和依他尼酸以相同剂量同时给药时，在豚鼠的柯蒂氏器中发现了非常严重的退化。从上述结果可以明显看出，当同时给予两种或更多种耳毒性药物时，它们对耳朵有增强作用，临床上应注意这一点。
