Schmid M
Leber Magen Darm. 1977 Aug;7(4):236-40.
Hepatic insufficiency results from extreme derangement of liver cell function. Pathophysiology and clinical picture of this syndrome are briefly discussed; the latter correlate rather poorly with laboratory data - the poorest correlation existing between clinical picture and bioptic findings. Acute hepatic insufficiency may occur in the course of every pathological process involving the liver, it does however arise most often in severe viral hepatitis with widespread disintegration of liver cells and in toxic liver damage. Chronic hepatic insufficiency is typical for the final stages of cirrhosis of the liver. Measurement of coagulation factors has proved to be the best prognostic parameter in hepatic failure.
肝功能不全是由肝细胞功能的严重紊乱引起的。本文简要讨论了该综合征的病理生理学和临床表现；后者与实验室数据的相关性较差——临床表现与活检结果之间的相关性最差。急性肝功能不全可能发生在任何涉及肝脏的病理过程中，然而最常见于肝细胞广泛崩解的严重病毒性肝炎和中毒性肝损伤。慢性肝功能不全是肝硬变终末期的典型表现。凝血因子的测定已被证明是肝衰竭中最佳的预后参数。
