Côté P Y, Levitt P, Parent A
Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
Hippocampus. 1996;6(5):483-94. doi: 10.1002/(SICI)1098-1063(1996)6:5<483::AID-HIPO2>3.0.CO;2-K.
The distribution of the limbic system-associated membrane protein in the amygdaloid complex and hippocampal formation of cynomolgus monkeys (Macaca fascicularis) was studied with immunohistochemical procedures. A highly complex and heterogeneous staining pattern is encountered in the macaque amygdala. The basal, lateral, and accessory basal nuclei display the most intense immunostaining with local heterogeneities. The lateral division of the central nucleus also stains intensely, whereas the medial division of the central nucleus and the medial nucleus are more weakly stained. The dorsal division of the bed nucleus-amygdala continuum (extended amygdala) is strongly immunoreactive. The hippocampus displays the strongest immunoreactivity encountered so far in the primate brain. The intensity of the immunostaining is highest in the cornu Ammonis (Ammon's horn; CA1-CA3 fields) and gradually decreases toward the dentate gyrus or the subicular area. In the hippocampus proper, the stratum radiatum, the pyramidal layer, the stratum oriens, and the alveus all display intense immunoreactivity. The immunostaining is much less prominent in the dentate gyrus, whose granule cell layer is completely devoid of labeling. In the subicular area, there is a lateromedial decreasing gradient in immunostaining intensity, the subiculum being moderately stained and the parasubiculum weakly stained. These results reveal that the limbic system-associated membrane protein labels structures that form the core of the limbic system in primates. Within each of these structures, however, the labeling is highly heterogeneous and appears to be confined to specific functional domains.
采用免疫组织化学方法研究了食蟹猴（猕猴）杏仁核复合体和海马结构中边缘系统相关膜蛋白的分布。猕猴杏仁核中出现高度复杂且异质性的染色模式。基底核、外侧核和副基底核显示出最强的免疫染色，且存在局部异质性。中央核的外侧部也强烈染色，而中央核的内侧部和内侧核染色较弱。杏仁核床核连续体（扩展杏仁核）的背侧部具有强烈的免疫反应性。海马显示出灵长类动物大脑中迄今为止最强的免疫反应性。免疫染色强度在海马角（海马结构；CA1-CA3区）最高，并朝着齿状回或下托区逐渐降低。在海马本身，辐射层、锥体细胞层、原层和脑室下带均显示出强烈的免疫反应性。齿状回的免疫染色则不那么明显，其颗粒细胞层完全没有标记。在下托区，免疫染色强度从外侧向内侧呈递减梯度，下托染色适中，旁下托染色较弱。这些结果表明，边缘系统相关膜蛋白标记了灵长类动物中构成边缘系统核心的结构。然而，在这些结构中的每一个结构内，标记都是高度异质性的，并且似乎局限于特定的功能域。
