François G, Van Looveren M, Timperman G, Chimanuka B, Aké Assi L, Holenz J, Bringmann G
Laboratorium voor Protozoölogie, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.
J Ethnopharmacol. 1996 Nov;54(2-3):125-30. doi: 10.1016/s0378-8741(96)01459-6.
The larvicidal activity of dionocophylline A, a naphthylisoquinoline alkaloid derived from the tropical vine Triphyophyllum peltatum (Dioncophyllaceae), was investigated against the malaria vector Anopheles stephensi. In direct and indirect inhibition assays it was demonstrated that the younger larval stages were very sensitive towards this natural product, with LC50 values below 1 mg/l. Pronounced effects were observed within 4 h of exposure. Aging larvae, however, were less sensitive, while pupae were totally insensitive to the action of dioncophylline A. The transformations from larvae to pupae and from pupae to adult mosquitoes remained unaffected. Therefore, dioncophylline A can be regarded as a promising specific larvicide.
对从热带藤本植物三角叶盾籽木（盾籽木科）中提取的萘基异喹啉生物碱——地奥诺考菲林A，针对疟疾媒介斯氏按蚊进行了杀幼虫活性研究。在直接和间接抑制试验中表明，较幼龄的幼虫阶段对这种天然产物非常敏感，半数致死浓度（LC50）值低于1毫克/升。在接触4小时内观察到明显效果。然而，老龄幼虫较不敏感，而蛹对地奥诺考菲林A的作用完全不敏感。从幼虫到蛹以及从蛹到成年蚊子的转变未受影响。因此，地奥诺考菲林A可被视为一种有前景的特效杀幼虫剂。
