Sato M, Fujiwara S, Tsuchiya H, Fujii T, Iinuma M, Tosa H, Ohkawa Y
Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan.
J Ethnopharmacol. 1996 Nov;54(2-3):171-6. doi: 10.1016/s0378-8741(96)01464-x.
Methanolic extracts obtained from 13 plants were studied for their antibacterial activity against cariogenic bacteria. Among them, the extract from Artocarpus heterophyllus showed the most intensive activity. Serial chromatographic purifications offered two active compounds which were identified as 6-(3-methyl-1-butenyl)-5,2',4'-trihydroxy-3-isoprenyl-7-methoxy flavone and 5,7,2',4'-tetrahydroxy-6-isoprenylflavone. Both isolates completely inhibited the growth of primary cariogenic bacteria at 3.13-12.5 micrograms/ml. They also exhibited the growth inhibitory effects on plaque-forming streptococci. These phytochemical isoprenylflavones would be potent compounds for the prevention of dental caries.
对从13种植物中获得的甲醇提取物进行了抗致龋菌抗菌活性研究。其中，波罗蜜提取物显示出最强的活性。通过连续色谱纯化得到了两种活性化合物，分别鉴定为6-(3-甲基-1-丁烯基)-5,2',4'-三羟基-3-异戊烯基-7-甲氧基黄酮和5,7,2',4'-四羟基-6-异戊烯基黄酮。两种分离物在3.13-12.5微克/毫升时完全抑制主要致龋菌的生长。它们对形成菌斑的链球菌也表现出生长抑制作用。这些植物化学异戊烯基黄酮可能是预防龋齿的有效化合物。
