Crossley J A, Berry E, Aitken D A, Connor J M
Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow, U.K.
Prenat Diagn. 1996 Nov;16(11):1039-42. doi: 10.1002/(SICI)1097-0223(199611)16:11<1039::AID-PD985>3.0.CO;2-#.
From around 91,000 women having routine prenatal screening for Down's syndrome and neural tube defects between July 1992 and October 1995, 261 women were identified as having insulin-dependent diabetes mellitus (IDDM). Alpha-fetoprotein (AFP) and human chorionic gonadotrophin (hCG) levels were reduced in these women, with median levels of 0.89 and 0.91 multiples of the median (MOM), respectively. The IDDM patients had a median weight which was 6 kg heavier than that of non-IDDM women. After correction for maternal weight, the AFP and hCG levels in the IDDM patients were 0.98 and 0.92 MOM, respectively. In routine practice, using results which were not weight-corrected, the IDDM women were neither over- nor under-represented in the high-risk group for Down's syndrome, but showed a tendency to be under-represented in the high-risk group for neural tube defects.
在1992年7月至1995年10月期间，对约91,000名进行唐氏综合征和神经管缺陷常规产前筛查的女性进行了研究，其中261名女性被确诊为胰岛素依赖型糖尿病（IDDM）。这些女性的甲胎蛋白（AFP）和人绒毛膜促性腺激素（hCG）水平降低，中位数水平分别为中位数倍数（MOM）的0.89和0.91。IDDM患者的中位数体重比非IDDM女性重6千克。校正孕妇体重后，IDDM患者的AFP和hCG水平分别为0.98 MOM和0.92 MOM。在常规实践中，使用未经体重校正的结果时，IDDM女性在唐氏综合征高危组中的比例既没有过高也没有过低，但在神经管缺陷高危组中的比例有偏低的趋势。
