兽疫链球菌4881产生的一种类溶葡萄球菌溶菌剂的作用模式
Mode of action of a lysostaphin-like bacteriolytic agent produced by Streptococcus zooepidemicus 4881.
作者信息
Simmonds R S, Pearson L, Kennedy R C, Tagg J R
机构信息
Department of Microbiology, University of Otago, Dunedin, New Zealand.
出版信息
Appl Environ Microbiol. 1996 Dec;62(12):4536-41. doi: 10.1128/aem.62.12.4536-4541.1996.
Abstract
Electron microscopy of zoocin A-treated sensitive streptococcus cells revealed cytoplasmic disruption and ultimately complete rupture of the cell wall. Culture viability and optical density were shown to decrease rapidly and simultaneously in Streptococcus pyogenes FF22 but less quickly in the relatively more resistant Streptococcus mutans 10449. Zoocin A was shown to cleave hexaglycine in a colorimetric cell-free microtiter assay system, and it is concluded that the killing action of zoocin A, like that of lysostaphin, is most probably the result of direct cleavage of the peptidoglycan cross-links in the cell wall. The relationship between sensitivity to zoocin A and the peptidoglycan cross-linkage structure of Streptococcus zooepidemicus, Lactococcus spp., S. pyogenes, Streptococcus gordonii, Streptococcus oralis, S. mutans, and Streptococcus rattus has been evaluated.
摘要
用电子显微镜观察经动物链菌素A处理的敏感链球菌细胞，发现细胞质遭到破坏，最终细胞壁完全破裂。在化脓性链球菌FF22中，培养物活力和光密度迅速且同时下降，但在相对更具抗性的变形链球菌10449中下降速度较慢。在比色无细胞微量滴定分析系统中，动物链菌素A可裂解六甘氨酸，由此得出结论，动物链菌素A的杀菌作用，与溶葡萄球菌素一样，很可能是细胞壁中肽聚糖交联键直接裂解的结果。已经评估了兽疫链球菌、乳球菌属、化脓性链球菌、戈登链球菌、口腔链球菌、变形链球菌和鼠链球菌对动物链菌素A的敏感性与肽聚糖交联结构之间的关系。
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