负责蜜蜂抗菌肽抗菌作用的氨基酸残基的功能图谱分析。
Functional mapping of amino acid residues responsible for the antibacterial action of apidaecin.
作者信息
Taguchi S, Ozaki A, Nakagawa K, Momose H
机构信息
Department of Biological Science and Technology, Science University of Tokyo, Chiba, Japan.
出版信息
Appl Environ Microbiol. 1996 Dec;62(12):4652-5. doi: 10.1128/aem.62.12.4652-4655.1996.
Abstract
Functional mapping was carried out to address the amino acid residues responsible for the activity of the antibacterial peptide apidaecin from the honeybee by an in vivo assay system developed previously. The C-terminal region and many of the proline and arginine residues which are present at high frequency in apidaecin were found to play an important role in its antibacterial activity.
摘要
通过先前开发的体内测定系统进行功能图谱分析，以确定负责蜜蜂抗菌肽apidaecin活性的氨基酸残基。发现apidaecin中高频出现的C末端区域以及许多脯氨酸和精氨酸残基在其抗菌活性中起重要作用。
相似文献
1
Functional mapping of amino acid residues responsible for the antibacterial action of apidaecin.负责蜜蜂抗菌肽抗菌作用的氨基酸残基的功能图谱分析。
Appl Environ Microbiol. 1996 Dec;62(12):4652-5. doi: 10.1128/aem.62.12.4652-4655.1996.
2
In vivo monitoring system for structure-function relationship analysis of the antibacterial peptide apidaecin.
Appl Environ Microbiol. 1994 Oct;60(10):3566-72. doi: 10.1128/aem.60.10.3566-3572.1994.
3
Production of antibacterial peptide 'apidaecin' using the secretory expression system of Streptomyces.
Biosci Biotechnol Biochem. 1993 Jul;57(7):1206-7. doi: 10.1271/bbb.57.1206.
4
Functional mapping of apidaecin through secondary structure correlation.通过二级结构相关性对蜜蜂防御素进行功能图谱分析。
Int J Biochem Cell Biol. 2008;40(5):1005-15. doi: 10.1016/j.biocel.2007.11.005. Epub 2007 Nov 17.
5
Molecular cloning of a putative homolog of proline/arginine-rich antibacterial peptides from porcine bone marrow.
FEBS Lett. 1993 Dec 27;336(2):284-8. doi: 10.1016/0014-5793(93)80821-b.
6
Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine.从嗜中性粒细胞中鉴定出一种富含脯氨酸和精氨酸的抗菌肽，它类似于小肠抗菌肽PR-39。
J Leukoc Biol. 1994 Dec;56(6):807-11. doi: 10.1002/jlb.56.6.807.
7
Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance.
J Biol Chem. 1994 Oct 21;269(42):26107-15.
8
Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea).从欧洲熊蜂（Bombus pascuorum，膜翅目，蜜蜂总科）中分离出的新型抗菌肽。
Insect Biochem Mol Biol. 1997 May;27(5):413-22. doi: 10.1016/s0965-1748(97)00013-1.
9
Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II.一种源自组蛋白H2A的抗菌肽蟾蜍 Buforin II 的结构-活性分析：脯氨酸铰链负责蟾蜍 Buforin II 的细胞穿透能力。
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8245-50. doi: 10.1073/pnas.150518097.
10
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.抗菌肽：线性和环状果蝇抗菌肽及蜜蜂抗菌肽1b类似物的合成与抗菌活性
J Med Chem. 2002 Sep 26;45(20):4494-504. doi: 10.1021/jm020861d.
引用本文的文献
1
Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects.昆虫中 II 型富含脯氨酸的抗菌肽的活性、结构和多样性。
EMBO Rep. 2024 Nov;25(11):5194-5211. doi: 10.1038/s44319-024-00277-5. Epub 2024 Oct 16.
2
Sequence diversity of apidaecin-like peptides arresting the terminating ribosome.抗菌肽样肽终止核糖体的序列多样性。
Nucleic Acids Res. 2024 Aug 27;52(15):8967-8978. doi: 10.1093/nar/gkae567.
3
Structure-Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin.抗菌肽天然产物天蚕素的结构-活性关系。
J Med Chem. 2023 Sep 14;66(17):11831-11842. doi: 10.1021/acs.jmedchem.3c00406. Epub 2023 Aug 21.
4
Inhibition of translation termination by the antimicrobial peptide Drosocin.抗菌肽 Drosocin 抑制翻译终止。
Nat Chem Biol. 2023 Sep;19(9):1082-1090. doi: 10.1038/s41589-023-01300-x. Epub 2023 Mar 30.
5
Charting the sequence-activity landscape of peptide inhibitors of translation termination.绘制肽类翻译终止抑制剂的序列-活性图谱。
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). doi: 10.1073/pnas.2026465118.
6
High-level heterologous production and Functional Secretion by recombinant Pichia pastoris of the shortest proline-rich antibacterial honeybee peptide Apidaecin.利用重组毕赤酵母进行高水平异源表达和功能分泌最短的富含脯氨酸的抗菌性蜜蜂肽 Apidaecin。
Sci Rep. 2017 Nov 6;7(1):14543. doi: 10.1038/s41598-017-15149-3.
7
Targeted engineering of the antibacterial peptide apidaecin, based on an in vivo monitoring assay system.基于体内监测分析系统的抗菌肽天蚕素的靶向工程。
Appl Environ Microbiol. 2009 Mar;75(5):1460-4. doi: 10.1128/AEM.02096-08. Epub 2008 Dec 29.
8
Enhanced accumulation and changed monomer composition in polyhydroxyalkanoate (PHA) copolyester by in vitro evolution of Aeromonas caviae PHA synthase.通过豚鼠气单胞菌聚羟基脂肪酸酯（PHA）合酶的体外进化增强聚羟基脂肪酸酯（PHA）共聚酯中的积累并改变单体组成
Appl Environ Microbiol. 2002 May;68(5):2411-9. doi: 10.1128/AEM.68.5.2411-2419.2002.
本文引用的文献
1
Apidaecin multipeptide precursor structure: a putative mechanism for amplification of the insect antibacterial response.蜜蜂防御肽多肽前体结构：昆虫抗菌反应放大的一种推测机制。
EMBO J. 1993 Apr;12(4):1569-78. doi: 10.1002/j.1460-2075.1993.tb05801.x.
2
3
Apidaecin-type peptide antibiotics function through a non-poreforming mechanism involving stereospecificity.
Biochem Biophys Res Commun. 1994 Feb 28;199(1):339-45. doi: 10.1006/bbrc.1994.1234.
4
In vivo monitoring system for structure-function relationship analysis of the antibacterial peptide apidaecin.
Appl Environ Microbiol. 1994 Oct;60(10):3566-72. doi: 10.1128/aem.60.10.3566-3572.1994.
5
Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance.
J Biol Chem. 1994 Oct 21;269(42):26107-15.
6
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.改良的M13噬菌体克隆载体和宿主菌株：M13mp18和pUC19载体的核苷酸序列。
Gene. 1985;33(1):103-19. doi: 10.1016/0378-1119(85)90120-9.
7
Apidaecins: antibacterial peptides from honeybees.蜜蜂防御肽：来自蜜蜂的抗菌肽。
EMBO J. 1989 Aug;8(8):2387-91. doi: 10.1002/j.1460-2075.1989.tb08368.x.
Zotero 插件