Miftakhov R N, Abdusheva G R
Laboratory of Numerical Methods in Mathematical Physics, Kazan State University, Russia.
Biol Cybern. 1996 Oct;75(4):331-8. doi: 10.1007/s004220050299.
Effects of Ca(2+)-activated K+ and voltage-activated K(+)-channel agonists and antagonists on the myoelectrical and contractile activity of a locus of the small bowel are simulated numerically. The model assumes that the electrical activity of smooth muscle syncytium is defined by kinetics of a mixture of L- and T-type Ca(2+)-channels, Ca(2+)-activated K+ and voltage-activated K(+)-channels, and leak Cl(-)-channels, and that the smooth muscle syncytium of the locus is a null-dimensional contractile system. The results of modelling, both qualitatively and quantitatively, reproduce the effects of forskolin, lemakalim, phencyclidine, charybdotoxin and high concentration of external K+ ions, on gastrointestinal motility. This is confirmed by comparison with experimental observations conducted on the smooth muscle preparations of different species.
数值模拟了Ca(2+)激活的K+通道和电压激活的K(+)通道激动剂及拮抗剂对小肠某一部位肌电活动和收缩活动的影响。该模型假定，平滑肌合胞体的电活动由L型和T型Ca(2+)通道、Ca(2+)激活的K+通道、电压激活的K(+)通道以及渗漏Cl(-)通道的混合物的动力学所定义，且该部位的平滑肌合胞体是一个零维收缩系统。建模结果在定性和定量方面均再现了福斯可林、雷马卡林、苯环利定、查尔霉素和高浓度细胞外K+离子对胃肠运动的影响。通过与在不同物种平滑肌制剂上进行的实验观察结果相比较，证实了这一点。
