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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.

J Auton Pharmacol. 2000 Aug;20(4):207-19. doi: 10.1046/j.1365-2680.2000.00183.x.

Electromechanical coupling in smooth muscle serves to coordinate the contractile activity of the syncytium. Electrical activity of smooth muscle of the gut is generated by ionic conductances that regulate and in turn are regulated by the membrane potential of smooth muscle cells. This activity determines the extent of Ca2+ entry into smooth muscle cells, and thus, the timing and intensity of contractions. 2. Potassium channels play an important role in regulating the excitability of the syncytium. The different types of K+ channel are characterized by different sensitivities to membrane potential, to intracellular Ca2+ levels and to modulation by agonists. 3. This review highlights the different types of K+ channels found in gut smooth muscle and describes their possible roles in regulating the electrical activity of the muscle.

平滑肌中的机电偶联有助于协调合胞体的收缩活动。肠道平滑肌的电活动由离子电导产生，这些离子电导调节平滑肌细胞的膜电位，反过来又受其调节。这种活动决定了Ca2+进入平滑肌细胞的程度，从而决定了收缩的时间和强度。2. 钾通道在调节合胞体的兴奋性方面起着重要作用。不同类型的K+通道对膜电位、细胞内Ca2+水平和激动剂调节具有不同的敏感性。3. 本综述重点介绍了在肠道平滑肌中发现的不同类型的K+通道，并描述了它们在调节肌肉电活动中的可能作用。

Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.

J Auton Pharmacol. 2000 Aug;20(4):207-19. doi: 10.1046/j.1365-2680.2000.00183.x.

Electromechanical coupling in smooth muscle serves to coordinate the contractile activity of the syncytium. Electrical activity of smooth muscle of the gut is generated by ionic conductances that regulate and in turn are regulated by the membrane potential of smooth muscle cells. This activity determines the extent of Ca2+ entry into smooth muscle cells, and thus, the timing and intensity of contractions. 2. Potassium channels play an important role in regulating the excitability of the syncytium. The different types of K+ channel are characterized by different sensitivities to membrane potential, to intracellular Ca2+ levels and to modulation by agonists. 3. This review highlights the different types of K+ channels found in gut smooth muscle and describes their possible roles in regulating the electrical activity of the muscle.

平滑肌中的机电偶联有助于协调合胞体的收缩活动。肠道平滑肌的电活动由离子电导产生，这些离子电导调节平滑肌细胞的膜电位，反过来又受其调节。这种活动决定了Ca2+进入平滑肌细胞的程度，从而决定了收缩的时间和强度。2. 钾通道在调节合胞体的兴奋性方面起着重要作用。不同类型的K+通道对膜电位、细胞内Ca2+水平和激动剂调节具有不同的敏感性。3. 本综述重点介绍了在肠道平滑肌中发现的不同类型的K+通道，并描述了它们在调节肌肉电活动中的可能作用。