外周脂肪酸动员在2-巯基乙醇诱导的脂肪肝中的作用及机制
Role and mechanism of peripheral fatty acid mobilization in 2-mercaptoethanol-induced fatty liver.
作者信息
Sabourault D, Giudicelli Y, Nordmann J, Nordmann R
出版信息
Lipids. 1977 Aug;12(8):641-4. doi: 10.1007/BF02533758.
PMID:895414
Abstract
2-Mercaptoethanol-induced fatty liver involves an increased free fatty acid mobilization which is primarily due to an inhibition of free fatty acid reesterification in adipose tissue. Furthermore, increased free fatty acid mobilization as well as fatty liver induction are not induced by 2-mercaptoethanol per se but result most probably from 2-mercaptoacetate through oxidation of 2-mercaptoethanol.
摘要
2-巯基乙醇诱导的脂肪肝涉及游离脂肪酸动员增加，这主要是由于脂肪组织中游离脂肪酸再酯化受到抑制。此外，游离脂肪酸动员增加以及脂肪肝的诱导并非由2-巯基乙醇本身引起，而极有可能是2-巯基乙醇氧化生成的2-巯基乙酸所致。
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