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1
The enzymic reduction of nicotinamide-adenine dinucleotide by 2-mercaptoethanol.2-巯基乙醇对烟酰胺腺嘌呤二核苷酸的酶促还原作用。
Biochem J. 1965 Nov;97(2):475-8. doi: 10.1042/bj0970475.
2
Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+).NAD⁺的无环烟酰胺类似物对马肝醇脱氢酶底物特异性的改变
DNA Repair (Amst). 2014 Nov;23:95-100. doi: 10.1016/j.dnarep.2014.09.005. Epub 2014 Oct 3.
3
Affinity chromatography of nicotinamide-adenine dinucleotide-linked dehydrogenases on immobilized derivatives of the dinucleotide.烟酰胺腺嘌呤二核苷酸连接的脱氢酶在二核苷酸固定化衍生物上的亲和层析
Biochem J. 1973 Dec;135(4):595-607. doi: 10.1042/bj1350595.
4
Decreased thermal stability of alcohol dehydrogenase in the presence of oxidized nicotinamide-adenine dinucleotide or oxidized nicotinamide-adenine dinucleotide phosphate.在存在氧化型烟酰胺腺嘌呤二核苷酸或氧化型烟酰胺腺嘌呤二核苷酸磷酸的情况下，乙醇脱氢酶的热稳定性降低。
Biochem J. 1971 Jun;123(2):8P. doi: 10.1042/bj1230008pa.
5
Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors.烟酰胺腺嘌呤二核苷酸氧化还原辅因子的提取与定量。
Antioxid Redox Signal. 2018 Jan 20;28(3):167-179. doi: 10.1089/ars.2017.7014. Epub 2017 Jul 19.
6
A fluorescent analog of nicotinamide adenine dinucleotide.烟酰胺腺嘌呤二核苷酸的一种荧光类似物。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2039-42. doi: 10.1073/pnas.69.8.2039.
7
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver.大鼠肝脏细胞质和线粒体中游离烟酰胺腺嘌呤二核苷酸的氧化还原状态。
Biochem J. 1967 May;103(2):514-27. doi: 10.1042/bj1030514.
8
Inhibition by ethanol, acetaldehyde and trifluoroethanol of reactions catalysed by yeast and horse liver alcohol dehydrogenases.乙醇、乙醛和三氟乙醇对酵母和马肝醇脱氢酶催化反应的抑制作用。
Biochem J. 1978 Jun 1;171(3):613-27. doi: 10.1042/bj1710613.
9
Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.肝脏乙醇脱氢酶双突变体的活性位点修饰：两种酶-配体复合物的结构研究
Biochemistry. 1998 Jun 30;37(26):9295-304. doi: 10.1021/bi973184b.
10
Affinity chromatography of yeast nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase on immobilized nicotinamide-adenine dinucleotide. Effects of ligands.酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶在固定化烟酰胺腺嘌呤二核苷酸上的亲和层析。配体的影响。
Ital J Biochem. 1977 Nov-Dec;26(6):486-96.

引用本文的文献

1
2-Mercaptoacetate administration depresses the beta-oxidation pathway through an inhibition of long-chain acyl-CoA dehydrogenase activity.给予2-巯基乙酸通过抑制长链酰基辅酶A脱氢酶活性来抑制β-氧化途径。
Biochem J. 1981 Jun 15;196(3):803-9. doi: 10.1042/bj1960803.
2
Role and mechanism of peripheral fatty acid mobilization in 2-mercaptoethanol-induced fatty liver.外周脂肪酸动员在2-巯基乙醇诱导的脂肪肝中的作用及机制
Lipids. 1977 Aug;12(8):641-4. doi: 10.1007/BF02533758.

本文引用的文献

1
THE INHIBITION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE-LINKED 3-ALPHA-HYDROXY STEROID DEHYDROGENASE BY CERTAIN ANTIMETABOLIC DRUGS.某些抗代谢药物对烟酰胺腺嘌呤二核苷酸连接的3-α-羟基类固醇脱氢酶的抑制作用。
Biochem J. 1965 Jun;95(3):847-50. doi: 10.1042/bj0950847.
2
Influence of sulfhydryl compounds on the equilibrium of the alcohol dehydrogenase reaction.
Arch Biochem Biophys. 1957 Nov;72(1):239-41. doi: 10.1016/0003-9861(57)90193-5.
3
Lipoic acid dehydrogenase in yeast.酵母中的硫辛酸脱氢酶。
Arch Biochem Biophys. 1956 Sep;64(1):242-3. doi: 10.1016/0003-9861(56)90257-0.
4
Competitive inhibition of hydroxylamine on alcohol dehydrogenase.羟胺对乙醇脱氢酶的竞争性抑制作用。
J Biol Chem. 1953 Apr;201(2):785-94.

2-巯基乙醇对烟酰胺腺嘌呤二核苷酸的酶促还原作用。

The enzymic reduction of nicotinamide-adenine dinucleotide by 2-mercaptoethanol.

作者信息

Lambe R F, Williams D C

机构信息

The Research Department, The Marie Curie Memorial Foundation, Caterham, Surrey.

出版信息

Biochem J. 1965 Nov;97(2):475-8. doi: 10.1042/bj0970475.

DOI:10.1042/bj0970475
PMID:16749153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1264664/
Abstract
  1. The reduction of NAD(+), by an enzyme preparation from rat liver, in the presence of 2-mercaptoethanol is reported. 2. It is suggested that the NAD(+)-linked alcohol dehydrogenase in the extract transfers hydrogen from 2-mercaptoethanol to NAD(+). 3. Both yeast and horse-liver alcohol dehydrogenases were observed to reduce NAD(+) in the presence of 2-mercaptoethanol. 4. Some interactions of 2-mercaptoethanol, cysteine or hydroxylamine with the alcohol dehydrogenases from rat liver, horse liver and yeast are discussed.
摘要
  1. 据报道，在2-巯基乙醇存在的情况下，大鼠肝脏的一种酶制剂可使NAD(+)还原。2. 有人提出，提取物中与NAD(+)相关的乙醇脱氢酶将氢从2-巯基乙醇转移至NAD(+)。3. 观察到酵母和马肝乙醇脱氢酶在2-巯基乙醇存在时均可使NAD(+)还原。4. 讨论了2-巯基乙醇、半胱氨酸或羟胺与大鼠肝脏、马肝脏及酵母的乙醇脱氢酶之间的某些相互作用。