Morris K J, Collier C G, Eastes W, Launder K A
Harwell Laboratory, Didcot, UK.
Exp Toxicol Pathol. 1996 Nov;48(6):490-3. doi: 10.1016/S0940-2993(96)80063-7.
Thirty three female Fischer-344 rats were intra-peritoneally (IP) injected with 5 mg of an experimental glass fibre designated X7753. This fibre type had an in vitro dissolution rate of 600 ng cm-2h-1. Groups of three rats were killed at various times up to one year after injection. The diaphragm and any fibre nodules were removed from the carcass and separately digested using hypochlorite solution, to recover the fibres. The number and morphometry of the fibres was measured using phase contrast optical microscopy (PCOM) and semi-automatic image analysis. The data obtained were compared to the previous studies of the durability of the X7753 fibres in the lung.
33只雌性Fischer - 344大鼠通过腹腔注射5毫克名为X7753的实验性玻璃纤维。这种纤维类型的体外溶解速率为600纳克/平方厘米·小时。在注射后的长达一年的不同时间点，每组三只大鼠被处死。从尸体上取出膈肌和任何纤维结节，并分别用次氯酸盐溶液消化，以回收纤维。使用相差光学显微镜（PCOM）和半自动图像分析测量纤维的数量和形态。将获得的数据与先前关于X7753纤维在肺中的耐久性的研究进行比较。
