Wagner J, Gordon L A, Heng H H, Tremblay M L, Olsen A S
McGill University, Department of Biochemistry, Montreal, Quebec, Canada.
Genomics. 1996 Nov 15;38(1):76-8. doi: 10.1006/geno.1996.0594.
Receptor type protein tyrosine phosphatase sigma (PTPRS), a member of a subfamily of receptor type protein tyrosine phosphatases, has been mapped to human chromosome 19p13.3 using fluorescence in situ hybridization (FISH) analysis. Hybridization analysis of chromosome 19 library cosmids has revealed several positive clones that are part of a contig located in the same region. The location of this contig was verified since one of the cosmid clones is anchored to a high-resolution FISH map of human chromosome 19p. In addition, the location of this gene relative to previously mapped proximal markers reveals a new point in the human-mouse synteny map by extending the mouse chromosome 17 synteny region in the telomeric direction.
受体型蛋白酪氨酸磷酸酶σ（PTPRS）是受体型蛋白酪氨酸磷酸酶亚家族的成员之一，已通过荧光原位杂交（FISH）分析定位到人类染色体19p13.3。对19号染色体文库黏粒的杂交分析揭示了几个阳性克隆，它们是位于同一区域的重叠群的一部分。由于其中一个黏粒克隆被锚定到人类染色体19p的高分辨率FISH图谱上，因此该重叠群的位置得到了验证。此外，该基因相对于先前定位的近端标记的位置通过在端粒方向上扩展小鼠17号染色体的同线性区域，揭示了人类-小鼠同线性图谱中的一个新位点。
