Soncin F, Calderwood S K
Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Biochem Biophys Res Commun. 1996 Dec 13;229(2):479-84. doi: 10.1006/bbrc.1996.1829.
Heat shock factor-1 (HSF-1), the transcriptional activator of heat shock genes has recently been shown to play a role in the repression of acute phase genes. We have further explored the role of HSF-1 in inflammatory processes in human monocytes. HSF-1 was activated in these cells by a wide range of classes of non-steroidal antiinflammatory drugs (NSAIDs) while being strongly repressed by pro-inflammatory stimuli. The experiments indicate reciprocal regulation of the acute phase and heat shock responses and suggest a novel target for the NSAID family of drugs.
