Santiago J V, Haymond M W, Clarke W L, Pagliara A S
Metabolism. 1977 Oct;26(10):1115-22. doi: 10.1016/0026-0495(77)90038-5.
Ten normal adults and ten nondiabetic massively obese subjects were studied following 4--7 days on identical diets. Intravenous arginine challenge resulted in similar glucose and glucagon responses and threefold greater integrated insulin responses in the obese when compared to the normal subjects. Following oral glucose, glucagon responses were similar, whereas both basal and integrated insulin values were higher in the obese subjects. Basal and integrated insulin concentrations were greater during intravenous glucose testing in the obese subjects, whereas similar glucagon suppression was observed in both groups. Hourly blood samples obtained during a 24-hr period revealed that the obese glucose profile differed significantly from the normals. Insulin values were two- to four-fold higher in the obese subjects, whereas no significant difference was observed in the glucagon concentrations. The nadir and peak glucagon concentrations for both groups occurred at 8:00 a.m. and 8:00 p.m., respectively, and were positively correlated with plasma amino acid values, and were similar in both groups.
对10名正常成年人和10名非糖尿病的极度肥胖受试者进行了研究，他们遵循相同饮食4至7天。静脉注射精氨酸激发试验显示，与正常受试者相比，肥胖受试者的葡萄糖和胰高血糖素反应相似，但胰岛素综合反应大三倍。口服葡萄糖后，胰高血糖素反应相似，而肥胖受试者的基础胰岛素值和胰岛素综合值均较高。在静脉注射葡萄糖测试期间，肥胖受试者的基础胰岛素浓度和胰岛素综合浓度较高，而两组的胰高血糖素抑制情况相似。在24小时内每小时采集的血样显示，肥胖者的血糖曲线与正常人有显著差异。肥胖受试者的胰岛素值高出两到四倍，而胰高血糖素浓度未观察到显著差异。两组的胰高血糖素浓度最低点和峰值分别出现在上午8:00和晚上8:00，与血浆氨基酸值呈正相关，且两组相似。
