宿主因素与HIV所致疾病的发病机制。
Host factors and the pathogenesis of HIV-induced disease.
作者信息
Fauci A S
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Nature. 1996 Dec 12;384(6609):529-34. doi: 10.1038/384529a0.
DOI:10.1038/384529a0
PMID:8955267
Abstract
The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.
摘要
患者体内人类免疫缺陷病毒（HIV）的复制水平反映了刺激性和抑制性宿主因素（尤其是内源性细胞因子）之间的平衡。有关HIV细胞共受体以及不同病毒株细胞嗜性的新信息将增进我们对HIV诱导发病机制的理解，并提示新的治疗和预防策略。
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