抗病毒治疗前血清ADAM17水平与HIV患者免疫重建相关。

Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution.

作者信息

Lin Ying, Chen Ming, Zhu Xuelian, Sun Suyu, Hu Xingzhong

机构信息

Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou, 325000, China.

The Third Affiliated Hospital of Wenzhou Medical University, Ruian 325200, Zhejiang, China.

出版信息

Heliyon. 2024 Nov 28;10(23):e40734. doi: 10.1016/j.heliyon.2024.e40734. eCollection 2024 Dec 15.

DOI:10.1016/j.heliyon.2024.e40734

PMID:39717606

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11665352/

Abstract

BACKGROUND

The relationship between tumour necrosis factor (TNF) levels and disease progression is well-established. However, the impact of changes in the level of TNF hydrolase (A-disintegrin and metalloenzyme 17; ADAM17) in HIV patients remains to be fully elucidated.

METHODS

Between March 1 and December 31, 2017, data were collected from 64 HIV-positive individuals in Wenzhou. Based on their history of antiviral treatment at the time of enrollment, these patients were categorized into two cohorts: an antiviral-treated group and an untreated HIV group. Then, the serum ADAM17 levels of each group were measured and analysed.

RESULTS

In comparison to the antiviral-treated group and the control group, the untreated HIV group exhibited a significantly elevated serum ADAM17 level (p < 0.001). A significant negative correlation was observed between serum ADAM17 levels and CD4 T cell counts in the untreated HIV group (r = -0.486, p = 0.001). ROC curve analysis revealed that the pre-treatment serum ADAM17 level in the untreated HIV group had moderate diagnostic accuracy for the AIDS stage (area under the curve: 0.703, p = 0.028). Additionally, serum ADAM17 levels were positively correlated with ADAM17 expression on the surface of leukocytes (r = 0.367, p = 0.018).

CONCLUSION

Serum ADAM17 levels are significantly elevated in HIV patients and are correlated with disease progression and immune reconstitution.

摘要

背景

肿瘤坏死因子（TNF）水平与疾病进展之间的关系已得到充分证实。然而，HIV患者中TNF水解酶（A- 解整合素和金属蛋白酶17；ADAM17）水平变化的影响仍有待充分阐明。

方法

2017年3月1日至12月31日期间，收集了温州64例HIV阳性个体的数据。根据入组时的抗病毒治疗史，将这些患者分为两个队列：抗病毒治疗组和未治疗的HIV组。然后，测量并分析每组的血清ADAM17水平。

结果

与抗病毒治疗组和对照组相比，未治疗的HIV组血清ADAM17水平显著升高（p < 0.001）。在未治疗的HIV组中，血清ADAM17水平与CD4 T细胞计数之间存在显著负相关（r = -0.486，p = 0.001）。ROC曲线分析显示，未治疗的HIV组治疗前血清ADAM17水平对艾滋病阶段具有中等诊断准确性（曲线下面积：0.703，p = 0.028）。此外，血清ADAM17水平与白细胞表面ADAM17表达呈正相关（r = 0.367，p = 0.018）。