McEvilly R J, Erkman L, Luo L, Sawchenko P E, Ryan A F, Rosenfeld M G
Howard Hughes Medical Institute, University of California, San Diego, USA.
Nature. 1996 Dec 12;384(6609):574-7. doi: 10.1038/384574a0.
Specific families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class IV POU domain transcription factor Brn-3.0, and two highly related factors Brn-3.1 and Brn-3.2, are differentially expressed in the developing and mature mammalian nervous system. The expression pattern of Brn-3.0 suggested that it has an important role in the development of sensory ganglia, as well as red nucleus, inferior olive, and nucleus ambiguus. Analysis of mice null for the Brn-3.0 locus shows that Brn-3.0 is required for the survival of subpopulations of proprioceptive, mechanoreceptive and nociceptive sensory neurons, where deletion of the gene affects neurotrophin and neurotrophin-receptor gene expression. Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations.
特定的转录因子家族介导不同神经元表型的顺序成熟过程中的事件。其中一个家族的成员，IV类POU结构域转录因子Brn-3.0，以及两个高度相关的因子Brn-3.1和Brn-3.2，在发育中和成熟的哺乳动物神经系统中差异表达。Brn-3.0的表达模式表明它在感觉神经节以及红核、下橄榄核和疑核的发育中具有重要作用。对Brn-3.0基因座缺失的小鼠的分析表明，Brn-3.0是本体感觉、机械感受和伤害感受性感觉神经元亚群存活所必需的，该基因的缺失会影响神经营养因子和神经营养因子受体基因的表达。Brn-3.0的缺失还会改变特定中枢神经元群体的分化、迁移或存活。
