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2
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本文引用的文献

1
Establishing differential gene expression in sporulating Bacillus subtilis: phosphorylation of SpoIIAA (anti-anti-sigmaF) alters its conformation and prevents formation of a SpoIIAA/SpoIIAB/ADP complex.在枯草芽孢杆菌芽孢形成过程中建立差异基因表达：SpoIIAA（抗抗σF）的磷酸化改变其构象并阻止SpoIIAA/SpoIIAB/ADP复合物的形成。
Mol Microbiol. 1996 Feb;19(4):901-7. doi: 10.1046/j.1365-2958.1996.434964.x.
2
Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activities.枯草芽孢杆菌抗σB拮抗剂RsbV通过应激或饥饿诱导的磷酸酶活性重新激活
J Bacteriol. 1996 Sep;178(18):5456-63. doi: 10.1128/jb.178.18.5456-5463.1996.
3
Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis.腺苷核苷酸在枯草芽孢杆菌应激反应转录因子调控中的作用。
J Mol Biol. 1996 Jul 12;260(2):165-77. doi: 10.1006/jmbi.1996.0390.
4
Homologous pairs of regulatory proteins control activity of Bacillus subtilis transcription factor sigma(b) in response to environmental stress.同源的调节蛋白对控制枯草芽孢杆菌转录因子sigma(b)的活性，以应对环境压力。
J Bacteriol. 1996 Jul;178(13):3846-53. doi: 10.1128/jb.178.13.3846-3853.1996.
5
Relative levels and fractionation properties of Bacillus subtilis σ(B) and its regulators during balanced growth and stress.枯草芽孢杆菌σ(B)及其调控因子在平衡生长和应激过程中的相对水平及分级特性
J Bacteriol. 1996 Jul;178(13):3701-9 sigma. doi: 10.1128/jb.178.13.3701-9sigma.1996.
6
SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis.SpoIIE调控枯草芽孢杆菌芽孢形成过程中一种调节转录因子sigma F的蛋白质的磷酸化状态。
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3238-42. doi: 10.1073/pnas.93.8.3238.
7
Regulation of sigma B levels and activity in Bacillus subtilis.枯草芽孢杆菌中σB水平及活性的调控
J Bacteriol. 1993 Apr;175(8):2347-56. doi: 10.1128/jb.175.8.2347-2356.1993.
8
Bacillus subtilis sigma B is regulated by a binding protein (RsbW) that blocks its association with core RNA polymerase.枯草芽孢杆菌的σB受一种结合蛋白（RsbW）调控，该蛋白会阻止其与核心RNA聚合酶结合。
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2330-4. doi: 10.1073/pnas.90.6.2330.
9
The sigma B-dependent promoter of the Bacillus subtilis sigB operon is induced by heat shock.枯草芽孢杆菌sigB操纵子的σB依赖性启动子受热激诱导。
J Bacteriol. 1993 Apr;175(7):1929-35. doi: 10.1128/jb.175.7.1929-1935.1993.
10
Strategies for the identification of interacting proteins.相互作用蛋白的鉴定策略。
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1639-41. doi: 10.1073/pnas.90.5.1639.

酵母双杂交系统检测枯草芽孢杆菌σB调节因子之间的相互作用。

The yeast two-hybrid system detects interactions between Bacillus subtilis sigmaB regulators.

作者信息

Voelker U, Voelker A, Haldenwang W G

机构信息

Institute für Mikrobiologie und Molecularbiologié, Einst-Moritz-Arndt-Universität, Greifswald, Germany.

出版信息

J Bacteriol. 1996 Dec;178(23):7020-3. doi: 10.1128/jb.178.23.7020-7023.1996.

DOI:10.1128/jb.178.23.7020-7023.1996
PMID:8955331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178610/
Abstract

SigmaB, the general stress response sigma factor of Bacillus subtilis, is regulated by the products of seven genes (rsbR, S, T, U, V, W, and X) with which it is cotranscribed. Biochemical techniques previously revealed physical associations among RsbW, RsbV, and sigmaB but failed to detect interactions of RsbR, S, T, U, or X with each other or RsbV, RsbW, or sigmaB. Using the yeast two-hybrid system, we have now obtained evidence for such interactions. The yeast reporter system was activated when RsbS was paired with either RsbR or RsbT, RsbR was paired with RsbT, and RsbV was paired with either RsbU or RsbW. In addition, RsbW2 and RsbR2 dimer formation was detected. RsbX failed to show interactions with itself or any of the other sigB operon products.

摘要

SigmaB是枯草芽孢杆菌的一般应激反应σ因子，由与其共转录的7个基因（rsbR、S、T、U、V、W和X）的产物调控。先前的生化技术揭示了RsbW、RsbV和sigmaB之间的物理关联，但未能检测到RsbR、S、T、U或X彼此之间以及与RsbV、RsbW或sigmaB的相互作用。利用酵母双杂交系统，我们现在获得了此类相互作用的证据。当RsbS与RsbR或RsbT配对、RsbR与RsbT配对以及RsbV与RsbU或RsbW配对时，酵母报告系统被激活。此外，还检测到了RsbW2和RsbR2二聚体的形成。RsbX未能显示出与自身或sigB操纵子的任何其他产物的相互作用。