Kapas S, Cameron L A, Puddefoot J R, Hinson J P
Department of Biochemistry, Faculty of Medical Sciences, Queen Mary and Westfield College, London, UK.
FEBS Lett. 1996 Nov 18;397(2-3):186-90. doi: 10.1016/s0014-5793(96)01133-7.
This study investigated the ET(A) and ET(B) receptor subtypes in rat adrenal cortex. The ET(A) antagonist, BQ-123, inhibited the zona glomerulosa (zg), but not the inner zone (iz) response to ET-1. RES-701-1, the ET(B) antagonist, abolished the iz response to ET-1, but had less effect on the zg. [125I]ET-1 binding studies revealed two receptor subtypes in both zones, with ET(A) predominating in the zg, and ET(B) in the iz. These data suggest that the ET(A) subtype is functionally more important in the zg while the ET(B) receptor is the major subtype in the inner zones.
本研究调查了大鼠肾上腺皮质中的ET(A)和ET(B)受体亚型。ET(A)拮抗剂BQ-123抑制了球状带（zg）对ET-1的反应，但不影响内层（iz）对ET-1的反应。ET(B)拮抗剂RES-701-1消除了iz对ET-1的反应，但对zg的影响较小。[125I]ET-1结合研究显示，两个区域均存在两种受体亚型，ET(A)在zg中占主导，而ET(B)在iz中占主导。这些数据表明，ET(A)亚型在zg中功能上更为重要，而ET(B)受体是内层区域的主要亚型。
