Boulahdour H, Poncy J L, Berry J P, Galle P
SC 27 (INSERM), Laboratoire de Biophysique, Faculté de Médecine, Créteil, France.
Radiat Res. 1996 Dec;146(6):683-7.
Chronic intratracheal administration of 237Np to rate was performed during 6 weeks. The total dose administered was 45.8 kBq. Two methods, electron microscopy and electron probe X-ray microanalysis, were used to determine the intracellular sites of localization of 237Np. Clusters of dense granules were observed in nuclei of pneumocytes and proximal tubular cells of the kidneys. These clusters have been shown to contain neptunium associated with phosphorus, sulfur and calcium. Alterations of nuclei and ultrastructural cytoplasmic lesions were observed. The absorbed doses in lungs and kidneys were very low. These results suggest that the chemical toxicity of 237Np is more important than its radiological toxicity.
在6周内对大鼠进行237Np的慢性气管内给药。给药的总剂量为45.8 kBq。采用电子显微镜和电子探针X射线微分析两种方法来确定237Np在细胞内的定位位点。在肺细胞和肾近端小管细胞的细胞核中观察到致密颗粒簇。已表明这些簇含有与磷、硫和钙相关的镎。观察到细胞核的改变和超微结构的细胞质损伤。肺和肾中的吸收剂量非常低。这些结果表明，237Np的化学毒性比其放射毒性更重要。
