Ahsan N, Wiegand L A, Abendroth C S, Manning E C
Division of Nephrology/Hypertension, Milton S. Hershey Medical Center, Hershey, Pa 17033, USA.
Am J Nephrol. 1996;16(6):532-6. doi: 10.1159/000169055.
Intravenous IgG infusion has infrequently been reported to cause acute renal failure. In almost all these reports, a sucrose containing IgG product was believed to be the cause of renal injury. Sucrose-induced osmotic nephrosis has been well described in the literature. In this report, we describe a case of acute anuric renal failure following a large infusion of intravenous IgG containing sucrose. Urine cytology demonstrated typical osmotic injury to the renal tubular epithelial cells. Early recovery of renal function was achieved by dialytic removal of sucrose from the circulation.
静脉注射免疫球蛋白（IVIg）输注导致急性肾衰竭的报道较为罕见。在几乎所有这些报道中，含蔗糖的免疫球蛋白产品被认为是肾损伤的原因。蔗糖诱导的渗透性肾病在文献中已有充分描述。在本报告中，我们描述了一例在大量输注含蔗糖的静脉注射免疫球蛋白后发生急性无尿性肾衰竭的病例。尿液细胞学检查显示肾小管上皮细胞有典型的渗透性损伤。通过透析从循环中清除蔗糖，肾功能得以早期恢复。
