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1
Pseudoknot-dependent read-through of retroviral gag termination codons: importance of sequences in the spacer and loop 2.逆转录病毒gag终止密码子的假结依赖性通读：间隔区和环2中序列的重要性
EMBO J. 1994 Sep 1;13(17):4137-44. doi: 10.1002/j.1460-2075.1994.tb06731.x.
2
Structural elements of rps0 mRNA involved in the modulation of translational initiation and regulation of E. coli ribosomal protein S15.参与大肠杆菌核糖体蛋白S15翻译起始调控的rps0 mRNA的结构元件
Nucleic Acids Res. 1994 Jul 11;22(13):2538-46. doi: 10.1093/nar/22.13.2538.
3
Mutational analysis of the pseudoknot structure of the S15 translational operator from Escherichia coli.大肠杆菌S15翻译操纵子假结结构的突变分析
Mol Microbiol. 1994 Oct;14(1):31-40. doi: 10.1111/j.1365-2958.1994.tb01264.x.
4
The structure of an RNA pseudoknot that causes efficient frameshifting in mouse mammary tumor virus.一种在小鼠乳腺肿瘤病毒中引发高效移码的RNA假结结构。
J Mol Biol. 1995 Apr 14;247(5):963-78. doi: 10.1006/jmbi.1995.0193.
5
Ribosomal protein S15 from Escherichia coli modulates its own translation by trapping the ribosome on the mRNA initiation loading site.来自大肠杆菌的核糖体蛋白S15通过将核糖体捕获在mRNA起始加载位点来调节其自身的翻译。
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6
Ribosome initiation complex formation with the pseudoknotted alpha operon messenger RNA.核糖体与具有假结结构的α操纵子信使核糖核酸形成起始复合物。
J Mol Biol. 1993 Feb 5;229(3):609-22. doi: 10.1006/jmbi.1993.1067.
7
Post-transcriptional controls in bacteriophage T4: roles of the sequence-specific endoribonuclease RegB.噬菌体T4中的转录后调控：序列特异性核糖核酸内切酶RegB的作用
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8
Hydroxyl radical footprinting of ribosomal proteins on 16S rRNA.核糖体蛋白在16S rRNA上的羟基自由基足迹分析
RNA. 1995 Apr;1(2):194-209.
9
Analysis of the role of the pseudoknot component in the SRV-1 gag-pro ribosomal frameshift signal: loop lengths and stability of the stem regions.SRV-1 病毒gag-pro基因核糖体移码信号中假结元件的作用分析：环的长度及茎区稳定性
RNA. 1995 Apr;1(2):146-54.
10
Stabilised secondary structure at a ribosomal binding site enhances translational repression in E. coli.核糖体结合位点处稳定的二级结构增强了大肠杆菌中的翻译抑制作用。
J Mol Biol. 1995 Oct 20;253(2):277-90. doi: 10.1006/jmbi.1995.0552.

S15核糖体蛋白表达中的假结与翻译调控

Pseudoknot and translational control in the expression of the S15 ribosomal protein.

作者信息

Bénard L, Philippe C, Ehresmann B, Ehresmann C, Portier C

机构信息

UPR 9073 CNRS, IBPC, Paris, France.

出版信息

Biochimie. 1996;78(7):568-76. doi: 10.1016/s0300-9084(96)80003-4.

DOI:10.1016/s0300-9084(96)80003-4
PMID:8955900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7131963/
Abstract

Translational autocontrol of the expression of the ribosomal protein S15 proceeds through the transitory formation of a pseudoknot. A synopsis of the known data is used to propose a molecular model of the mechanism involved and for the role of the pseudoknot. This latter structure is able to recruit 30S ribosomal subunits to initiate translation, but also to bind S15 and to stop translation by trapping the ribosome on its loading site. Information on the S15 protein recognition of the messenger RNA site was deduced from mutational analyses and chemical probing. A comparison of this messenger site with the S15 ribosomal binding site was conducted by analysing hydroxyl radical footprintings of these two sites. The existence of two subsites in 16S RNA suggests that the ribosomal protein S15 might present either two different binding sites or at least one common subsite. Clues for the presence of a common site between the messenger and 16S RNA are given which cannot rule out that recognition specificity is linked to a few other determinants. Whether these determinants are different or not remains an open question.

摘要

核糖体蛋白S15表达的翻译自调控通过假结的瞬时形成进行。利用已知数据的概要提出了所涉及机制及其假结作用的分子模型。后一种结构能够募集30S核糖体亚基来启动翻译，但也能结合S15并通过将核糖体困在其加载位点来终止翻译。通过突变分析和化学探针推导了S15蛋白对信使RNA位点的识别信息。通过分析这两个位点的羟基自由基足迹，对该信使位点与S15核糖体结合位点进行了比较。16S RNA中存在两个亚位点表明核糖体蛋白S15可能具有两个不同的结合位点或至少一个共同的亚位点。给出了信使RNA与16S RNA之间存在共同位点的线索，但不能排除识别特异性与其他一些决定因素有关。这些决定因素是否不同仍然是一个悬而未决的问题。