Denti E, Walker J M, Brancaccio D, Tessore V
Med Instrum. 1977 Jul-Aug;11(4):212-6.
Hemodialysis is not very effective at removing middle molecular weight species and certain drugs such as salicylates and barbiturates. Carbon hemoperfusion is ineffective in removing urea and water, even when coated microparticles can be generated. To use the advantages of hemodialysis and carbon hemoperfusion without their disadvantages, cuprophan tubular membranes and fibers containing activated carbon have been manufactured. A device called the Hemocarbodialyser, consisting of a sorbent and dialyzing carbon membrane wound onto a coli dialyzer, has been evaluated by the authors. From preliminary results, the Hemocarbodialyser has been shown to be efficient at removing vitamin B12, has high ultrafiltration, and has high dialysance of creatinine and uric acid. The use of activated carbon and aluminum oxide fibers was also evaluated, indicating that fibers containing sorbents, as well as the Hemocarbodialyser, may have clinical importance in the near future, when joint hemodialysis and hemoperfusion is required in hepatic failure, uremia, and acute poisoning.
血液透析在清除中分子量物质以及某些药物（如水杨酸盐和巴比妥类药物）方面效果不佳。即使可以制造出包被微粒，碳血液灌流在清除尿素和水分方面也无效。为了利用血液透析和碳血液灌流的优点而避免其缺点，已制造出铜仿管状膜和含活性炭的纤维。作者评估了一种名为血液灌流透析器的装置，它由吸附剂和缠绕在结肠透析器上的透析碳膜组成。根据初步结果，血液灌流透析器已被证明在清除维生素B12方面有效，具有高超滤率，对肌酐和尿酸具有高透析率。还评估了活性炭和氧化铝纤维的使用，这表明含吸附剂的纤维以及血液灌流透析器在不久的将来，当肝衰竭、尿毒症和急性中毒需要联合血液透析和血液灌流时可能具有临床重要性。
