Woodside B, Amir S
Department of Psychology, Concordia University, Montreal, Qué., Canada.
Brain Res. 1996 Nov 11;739(1-2):339-42. doi: 10.1016/s0006-8993(96)01072-4.
It has been demonstrated in guinea pigs that nitric oxide synthase (NOS) activity is increased in late pregnancy in some peripheral tissues and in the cerebellum. To determine whether similar changes would be observed in areas of the brain known to play a role in parturition, staining for NADPH-diaphorase, a histochemical marker of NOS synthase, in the paraventricular (PVN) and supraoptic nuclei (SON) was compared among ovariectomized, virgin and late pregnant rats. The number of cells showing dense staining for NADPH-diaphorase increased in both the SON and PVN in late pregnancy compared to that observed in virgin and ovariectomized females. Thus, changes in reproductive state are associated with changes in NADPH-diaphorase staining in areas of the brain that are intimately involved in the control of reproductive function.
在豚鼠身上已证实，一氧化氮合酶（NOS）活性在妊娠后期某些外周组织和小脑中会增加。为了确定在已知参与分娩过程的脑区是否会观察到类似变化，对去卵巢大鼠、未孕大鼠和妊娠后期大鼠的室旁核（PVN）和视上核（SON）中作为NOS合酶组织化学标志物的NADPH - 黄递酶进行染色并比较。与未孕和去卵巢的雌性大鼠相比，妊娠后期SON和PVN中显示NADPH - 黄递酶强染色的细胞数量增加。因此，生殖状态的变化与大脑中紧密参与生殖功能控制区域的NADPH - 黄递酶染色变化相关。
