Lephart E D, Ladle D R, Jacobson N A, Rhees R W
Department of Zoology, Brigham Young University, Provo, UT 84602, USA.
Brain Res. 1996 Nov 11;739(1-2):356-60. doi: 10.1016/s0006-8993(96)01068-2.
Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion) as a function of increasing gestational age. Conversely, in Proscar-treated animals open-field values significantly increased on day 15 and 17 of gestation compared to control values. These data indicate that inhibition of MBH 5 alpha-reductase during pregnancy significantly increased open-field activity levels during late gestation in rats and provides evidence for a link between the production of 5 alpha-reduced metabolites of progesterone in brain and behavioral activity during pregnancy.
在怀孕大鼠中，使用已知抑制剂保列治（非那雄胺）可显著阻断内侧基底下丘脑（MBH）的5α-还原酶活性，同时在妊娠最后一周对其旷场行为进行量化。在对照动物中，旷场行为随着胎龄增加而显著降低（呈阶梯式）。相反，与对照值相比，在接受保列治治疗的动物中，妊娠第15天和第17天的旷场值显著增加。这些数据表明，孕期抑制MBH的5α-还原酶可显著提高大鼠妊娠后期的旷场活动水平，并为大脑中孕酮5α-还原代谢产物的产生与孕期行为活动之间的联系提供了证据。
