Valentino M
Clinica del Lavoro, Ospedale Regionale di Torrette, Italia.
Med Lav. 1996 Jul-Aug;87(4):289-96.
A group of 90 subjects affected by n-hexane polyneuropathy were studied again after at least one year from cessation of occupational exposure to the neurotoxic agent. Neurological examinations, conduction velocities and distal latencies in sensory (sural and median) and motor (peroneal and ulnar) nerves were evaluated in order to study the evolution of the disease. The percentage of subjects with abnormal leg deep tendon reflexes, leg cutaneous sensitivity or vibration sensation was statistically higher in subjects who had ceased n-hexane exposure for less than 10 years than in the other subjects; however, no differences between these two groups were found for electrophysiological parameters. A complete recovery of motor nerve velocities was found. On the contrary, sensory nerve velocities, sensory nerve distal latencies, as well as ulnar nerve latency, were statistically different from controls, even if they were also statistically different from the values which had been recorded at the time of diagnosis. We conclude that in n-hexane polyneuropathy motor nerve components improve, while the sensory nerves are more seriously affected and do not completely recover, even after more than 10 years without exposure to the toxic agent.
一组90名患有正己烷多发性神经病的受试者在停止职业性接触这种神经毒性物质至少一年后再次接受研究。对感觉神经（腓肠神经和正中神经）和运动神经（腓总神经和尺神经）进行神经学检查、测量传导速度和远端潜伏期，以研究疾病的进展情况。停止接触正己烷不到10年的受试者中，腿部深腱反射、腿部皮肤感觉或振动觉异常的受试者百分比在统计学上高于其他受试者；然而，两组在电生理参数方面未发现差异。运动神经速度完全恢复。相反，感觉神经速度、感觉神经远端潜伏期以及尺神经潜伏期与对照组相比在统计学上存在差异，即使它们与诊断时记录的值相比在统计学上也存在差异。我们得出结论，在正己烷多发性神经病中，运动神经成分有所改善，而感觉神经受到的影响更严重，即使在停止接触毒性物质超过10年后也不能完全恢复。
