Guldner G T, Morrell M J
Department of Neurology and Neurological Sciences, Stanford University Medical Center, California, USA.
Epilepsia. 1996 Dec;37(12):1211-4. doi: 10.1111/j.1528-1157.1996.tb00555.x.
Men with epilepsy appear to have an approximately fivefold increase in risk of erectile dysfunction (ED). We attempted to determine whether ED in men with epilepsy was due to a physiological basis and whether erectile function could be adequately evaluated with an ambulatory nocturnal penile tumescence and rigidity monitor.
The physiologic integrity of the sexual response in men with epilepsy and ED was assessed with an ambulatory nocturnal penile tumescence and rigidity monitor (NPTR). Six men with localization-related epilepsy of temporal lobe origin (TLE) and ED, 2 men with TLE and normal sexual function, and 1 man with nonepileptic seizures (NES) and ED underwent evaluation of nocturnal erections for at least 2 nights.
Five of 6 men with TLE and complaints of ED had abnormal ambulatory NPTR evaluations. All others had normal ambulatory NPTR. All abnormal evaluations showed reduced levels of rigidity, often with normal levels of tumescence.
Previous studies have shown this abnormal ambulatory NPTR pattern to be associated with neurogenic rather than vasogenic ED. Therefore, epilepsy-related ED may have a substantial neurophysiologic component.
癫痫男性出现勃起功能障碍（ED）的风险似乎增加了约五倍。我们试图确定癫痫男性的ED是否有生理基础，以及勃起功能是否可以通过便携式夜间阴茎肿胀和硬度监测仪进行充分评估。
使用便携式夜间阴茎肿胀和硬度监测仪（NPTR）评估癫痫合并ED男性的性反应生理完整性。6名患有颞叶起源的局灶性癫痫（TLE）并伴有ED的男性、2名患有TLE且性功能正常的男性以及1名患有非癫痫性发作（NES）并伴有ED的男性接受了至少两晚的夜间勃起评估。
6名患有TLE且主诉ED的男性中有5名便携式NPTR评估异常。其他所有人的便携式NPTR均正常。所有异常评估均显示硬度水平降低，肿胀水平通常正常。
先前的研究表明，这种异常的便携式NPTR模式与神经源性而非血管源性ED相关。因此，癫痫相关的ED可能有很大的神经生理成分。
