儿童急性淋巴细胞白血病中21号染色体的串联三倍体和四倍体
Tandem triplication and quadruplication of chromosome 21 in childhood acute lymphoblastic leukemia.
作者信息
Baialardo E M, Felice M S, Rossi J, Barreiro C, Gallego M S
机构信息
Laboratorio de Citogenética, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
出版信息
Cancer Genet Cytogenet. 1996 Nov;92(1):43-5. doi: 10.1016/s0165-4608(96)00151-3.
A 5-year-old girl with ALL was shown to have a leukemic clone characterized by a triplication and quadruplication of chromosome 21, arranged in tandem, at diagnosis and relapse, respectively. To our knowledge, this is the second report of this chromosomal anomaly in ALL, which was confirmed by in situ staining. The karyotype evolution in the leukemic clone from triplication to quadruplication at relapse emphasizes the association of chromosome 21 with hematopoietic malignancies.
一名患有急性淋巴细胞白血病（ALL）的5岁女孩在诊断和复发时，其白血病克隆分别表现为21号染色体串联三倍体和四倍体。据我们所知，这是ALL中这种染色体异常的第二篇报道，该异常通过原位染色得以证实。白血病克隆在复发时从三倍体演变为四倍体的核型变化强调了21号染色体与造血系统恶性肿瘤的关联。
Zotero 插件