一例儿童急性淋巴细胞白血病中21号染色体明显的串联四倍体。
An apparent tandem quadruplication of chromosome 21 in a case of childhood acute lymphoblastic leukemia.
作者信息
Dubé I D, el-Solh H
出版信息
Cancer Genet Cytogenet. 1986 Nov;23(3):253-6. doi: 10.1016/0165-4608(86)90185-8.
A case of childhood ALL is presented in which the leukemic clone had both normal chromosomes #21 replaced by a single marker chromosome that contained four copies of chromosome #21 arranged in tandem. This unique report further emphasizes the role played by multiple copies of chromosome #21 in acute leukemia. The observation of one cell in which the marker appeared to consist of only three copies of chromosome #21 arranged in tandem raises the possibility that the marker chromosome arose as a result of a stepwise amplification process.
本文报告了一例儿童急性淋巴细胞白血病（ALL）病例，其中白血病克隆的两条正常21号染色体均被一条标记染色体所取代，该标记染色体包含四个串联排列的21号染色体拷贝。这一独特报告进一步强调了21号染色体多拷贝在急性白血病中所起的作用。观察到一个细胞中的标记染色体似乎仅由三个串联排列的21号染色体拷贝组成，这增加了标记染色体是由逐步扩增过程产生的可能性。
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