González G J, Notohamiprodjo M
División de Genética, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
Cancer Genet Cytogenet. 1996 Nov;92(1):82-4. doi: 10.1016/0165-4608(94)00287-8.
Fluorescence in situ hybridization (FISH) study of bone marrow cells from a patient with clinically and immunologically acute leukemia showed that an apparent t(6;22)(p25; q11.2) identified by routine banding techniques concealed a complex t(6;9;22)(p25;q34; q11.2). This observation further supports the importance of FISH in those cases where a chromosome rearrangement could not be reliably detected by conventional cytogenetic study.
对一名临床和免疫诊断为急性白血病患者的骨髓细胞进行荧光原位杂交（FISH）研究显示，常规显带技术鉴定出的明显t(6;22)(p25; q11.2)隐藏着一个复杂的t(6;9;22)(p25;q34; q11.2)。这一观察结果进一步支持了在常规细胞遗传学研究无法可靠检测到染色体重排的情况下，FISH的重要性。
